The other AFM systems accessible to us
We have also access to a wide range of commercial AFMs that can achieve sub-nanometer vertical resolution under liquid conditions and can be combined with various extension kits allowing temperature control and in situ fluid exchange. These include: 3 Asylum Research MFP-3D AFMs, 2 Bruker Dimension ICON AFMs, and an Asylum Research Cypher AFM. Recently, we used these AFM systems to determine the effect of ionic liquids on cell membrane elasticity. Alterations in cell membrane elasticity are observed in several pathological conditions and are relevant in bacteria and virus dissemination. As a results, being able to act on cell elasticity with ionic liquids can lead to high-impact applications in drug-delivery, pharmacology, bio-medicine and, more in general, bio-nanotechnology.
MFP-3D stand alone AFM (Asylum Research).
MFP-3D AFM (Asylum Research) combined with an Olympus IX71 for phase contrast/brightfield correlative imaging.
MFP-3D AFM (Asylum Research) combined with a Nikon Ti/E for epi-fluorescence correlative imaging.
NanoWizard II bio-AFM (JPK) combined with a Nikon Ti/E for epi-fluorescence correlative imaging.
Cypher AFM (Asylum Research).
Dimension ICON XR AFM (Bruker).
Dimension ICON AFM (Bruker).